ADVISORS

Brigitte Boldyreff, Dr.rer.nat.habil, B.Sc .

Dr. Boldyreff has more than 20 years’ experience in commercial biotech. She is founder of Kinase Logistics ApS, a solo company which now currently serves as European Agent for the Japanese company Carna Biosciences. She holds a PhD degree in Molecular Biology from the Univ. of Lübeck, Germany and a BS degree in Human Nutrition and Health from the Univ. College Haderslev, Denmark. She works as Executive Director at Kinase Logistics ApS, as CSO at KinaseDetect ApS and had been Assoc. Professor at the Inst. of Biochem. and Molecular Biology, Univ. of Southern Denmark. She has a strong interest in receptor and signal transduction mechanisms as these related to mechanisms of action and efficacy, especially the physiological role of kinases and their role in diseases, as well as impact of nutrition on health. In addition, she has contributed >60 peer reviewed publications in numerous areas including oncology, vascular disease, and bone diseases, among others.

Gerald Haase, MD FACS

Dr. Gerald Haase, MD, FACS, CMA, has been actively involved in medical research and clinical trials for 35 years including the design of central venous access devices, applications for intra-operative radiation therapy in pediatric solid tumors, technical surgical innovations in adult and childhood cancer.  Dr. Haase also served as chairman of the Board of Scientific Counselors of the Cancer Treatment Research Fdn., and as a senior member of the Commission on Cancer of the Am. College of Surgeons. He was appointed to the Board of Trustees of the National Childhood Cancer Fdn. and served on its Medical & Scientific Advisory Board. He has published/ presented more than 200 scientific papers, is the inventor/co-inventor of 10 issued U.S. patents for micronutrient and phytonutrient therapy with 5 pending patents and been the recipient of clinical research grants/contracts funded at million-dollar cumulative levels.   Dr. Haase participated with the Intl. Office of the NCI and has been an examiner in pediatric surgery for the Am. Board of Surgery. He is a member of more than 25 professional societies including the AACR, Intl. College of Surgeons, Am. Acad. of Pediatrics, Am. College of Physician Executives, & is a charter member of the Intl. Soc. of Pediatric Surgical Oncology. Dr. Haase received his undergraduate degree from the Johns Hopkins University and M.D. degree from Tufts University School of Medicine with graduate honors in research. His surgical training was at the University of Colorado, Health Sciences Center and he specialized in pediatric surgery and oncology at Children’s Hospital Medical Center, Boston, and Nationwide Children’s Hospital, Columbus, Ohio.

Olaf-Georg Issinger, Dr. rer. nat. habil.

Dr. Issinger Professor emeritus at the Department for Biochemistry and Molecular Biology at the University of Southern Denmark – Odense, DK. Dr. Issinger is founder of KinaseDetect ApS, a privately held company involved in production and sale of protein kinases, substrates and antibodies for pharmaceutical industries. Dr. Issinger’s interest in protein kinase research began as a postdoctoral fellow at the Univ. of Calif. Davis. He continued his career as Assistant professor at the Univ. of Stuttgart and Associate professor at the Medical Faculty of Saarland University – Homburg/Saar, Germany. He worked as a guest scientist at the National Cancer Center in Tokyo (1986/87) and at the St. Vincent’s Institute, Melbourne, Australia (2009). He received several special awards and serves as reviewer on various boards and international Journals. Dr. Issinger received his M.S. from the Free University in Berlin and his Ph.D. from Freiburg University, Germany. Dr. Issinger has authored over 180 scientific articles in the fields of protein kinases, signal transduction and cancer.

Adel A. Mikhail, Ph.D.

Dr. Mikhail is the founder and CEO of Phylogeny Inc., a company that specializes in tissue analyses and molecular pathology.   Most recently, Dr. Mikhail has merged his company with two other organizations to form Discovery Life Sciences (Phylogeny, Conversant Bio, and Folio Bio).  Dr. Mikhail has more than 25 years in bio-corporate development, investment, and biotechnology applications to new and repurposed drugs and drug development.

George Q. Mills, M.D., M.B.A.

Dr. Mills has held several senior roles at the FDA, including as a Division Director in the Center for Drugs (CDER), Branch Chief and designated Acting Deputy Division Director of the Biologics Oncology Division at the Center for Biologics Evaluation and Research (CBER). In these roles, he provided expertise in medical diagnostic imaging and therapeutic radiopharmaceutical oncologic biologics and drugs. He also served as the CBER/CDER expert in conjunction with the review of radiographic imaging submissions in support of multiple licensure submissions. Dr. Mills also served as Vice President of Medical Imaging for Perceptive Informatics, a PAREXEL Company. Dr. Mills has spoken at numerous industry conferences and has published articles in scientific journals and industry publications on imaging and regulatory topics, including the FDA Critical Path Initiative. Dr. Mills has been certified by the American Board of Nuclear Medicine and the American Board of Pathology, Anatomic and Clinical Pathology. Dr. Mills holds a M.D. Degree from Creighton University in Omaha, Nebraska, a M.B.A. degree from Pepperdine University, and a B.A. degree from the University of Nebraska.

Kenneth C. Williams, Ph.D.

Dr. Williams is Full Professor in the Department of Molecular Biology at Boston College.  Dr. Williams’ work has centered on inflammation and normal and diseased states. This work includes, a) studies to define subpopulations of macrophages in the CNS and their precursors in blood and bone marrow, b) the role of the cellular immune system especially CD8 T cells controlling monocyte/macrophage activation and CNS pathogenesis, and c) developing drugs that target HIV and SIV infected/activated macrophages resulting in cell death or deactivation. In addition, we are exploring an exciting field of emergent populations of monocytes and dendritic cells that are expanded with disease. This work uses a monkey model of rapid, consistent AIDS and neuroAIDS, CD8 T lymphocyte depletion, MR spectroscopy, monocyte/macrophage biology and immunology. Dr. Williams has more than 18 years of experience in the field of inflammation and disease.